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Invitrogen™ IL-6 Human ProQuantum Immunoassay Kit
Measure cytokine proteins with small sample consumption and high sensitvity on a qPCR instrument
Brand: Invitrogen™ A35573
This item is not returnable.
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Description
Interleukin 6 (IL-6) is a multifunctional 26 kD protein originally discovered in the medium of RNA-stimulated fibroblastoid cells. IL-6 appears to be directly involved in the responses that occur after infection and cellular injury,and it may prove to be important as IL-1 and TNF-a in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts,activated T cells,activated monocytes or macrophages and endothelial cells. IL-6 acts upon a variety of cells including myeloid progenitor cells,T cells,B cells,and hepatocytes. In addition,IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors. IL-6 plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is a very useful culture supplement for the generation of a high number of antibody-producing hybridomas. Primarily produced at sites of acute and chronic inflammation,IL-6 is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor,alpha. The functioning of IL-6 is implicated in a wide variety of inflammation-associated disease states including diabetes mellitus and systemic juvenile rheumatoid arthritis.Specifications
P05231 | |
<0.05pg/mL | |
ProQuantum | |
Human | |
qPCR Instruments | |
BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 | |
FAM™ | |
RUO | |
-20°C | |
30 min. |
0.064 to 10000 pg/mL | |
Taqman™ Real-time PCR | |
Plasma, Serum, Supernatant | |
Cytokine protein quantitation | |
3569 | |
Assay Dilution Buffer<Br>Antibody-Conjugate A<Br>Antibody-Conjugate B<Br>Antibody-Conjugate Dilution Buffer<Br>Standard<Br>Master Mix<Br>Ligase | |
96 Tests | |
Serum, 2-5 μL; Supernatant, 2-5 μL; Plasma, 2-5 μL | |
Human | |
2 hr. |