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Gibco™ PeproGMP® Human IL-2 Recombinant Protein, PeproTech®

Product Code. 30275964
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Quantity:
1 mg
100 μg
50 μg
Unit Size:
100µg
1mg
50µg
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Product Code. 30275964

Brand: Gibco™ GMP2000250UG

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This item is not returnable. View return policy

Description

Recombinant Protein

Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond. Additional product information and specifications are provided on the Certificate of Analysis. All PeproGMP® products are manufactured using animal-derived component free materials. Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter 1043 Ancillary Materials for Cell, Gene, and Tissue-Engineered Products. Product use statement: For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.

Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P60568
For Use With (Application) Control, Western Blot Control, Bioactivity
Format Lyophilized
Formulation Protein with no preservative
Gene ID (Entrez) 3558
Molecular Weight (g/mol) 15.5 kDa
Name PeproGMP™ Human IL-2
Purification Method Purified
Quantity 50 μg
Storage Requirements -20°C or -80°C if preferred
Regulatory Status GMP
Endotoxin Concentration ≤0.1 EU/μg
Gene Alias aldesleukin; cytokine; H-IL-2; il 2; Il2; Il-2; ILN; Interleukin; interleukin 2; interleukin 2 precursor; interleukin 2 variant IL2delta2; Interleukin2; Interleukin-2; interleukin-2 precursor; interleukin-2 precursor protein; interleukin-2; interleukin 2; Involved in regulation of T cell clonal expansion; involved in regulation of T-cell clonal expansion; lymphokine; M-IL-2; patial sequence of Interleukin-2; POIL2; porcine Interleukin 2; T cell growth factor; T-cell growth factor; T-cell growth factor (TCGF); TCGF
Common Name IL-2
Gene Symbol IL2
Biological Activity Determined by the proliferation of mouse CTLL-2 cells. PeproGMP Recombinant Human IL-2 ha been tested against the WHO standard NIBSC 86/500.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFAQSII STLT
Content And Storage -20°Cor to +80°C if preferred
Activity Determined by the proliferation of mouse CTLL-2 cells. PeproGMP Recombinant Human IL-2 has been tested against the WHO standard NIBSC 86/500. Find the International Unit (IU) value <a href='https://www.thermofisher.com/us/en/home/life-science/cell-culture/cell-culture-learning-center/recombinant-protein-information/international-units.html'>here</a>.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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