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Ephrin B1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen 343500

Additional Details : Weight : 0.50000kg

Product Code. 10251653

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance.


Description

Description

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Specifications

Specifications

Ephrin B1
Polyclonal
Unconjugated
P98172, P52795
EFNB1
Synthetic peptide derived from the internal sequence of the mouse ephrin-B1 protein
100 μg
Primary
Human, Mouse
Antibody
IgG
Immunohistochemistry, Immunoprecipitation, Western Blot
0.25 mg/mL
EFNB1
EFL6, EFNB3, EPH related receptor transmembrane ligand ELK L3, EPH related receptor tyrosine kinase ligand 8, Ephrin B3, EPLG8, LERK8
Rabbit
Antigen affinity chromatography
RUO
13641, 1947
-20°C
Liquid
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