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Phospho-Tyrosine Hydroxylase (Ser19) Polyclonal Antibody, Invitrogen™

Rabbit Polyclonal Antibody

Brand:  Invitrogen PA538240

Additional Details : Weight : 0.00900kg

Product Code. 15595161

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance.


Description

Description

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson′s disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.
Specifications

Specifications

Phospho-Tyrosine Hydroxylase (Ser19)
Polyclonal
Unconjugated
TH
Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, TH, TYH
Rabbit
Antigen affinity chromatography
RUO
21823, 25085, 7054
-20°C
Liquid
Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
1 mg/mL
Dulbecco′s PBS with 150mM NaCl, 50% glycerol and 0.02% sodium azide; pH 7.4
P07101, P24529, P04177
TH
A synthetic phosphopeptide derived from human TyrHydroxylase around the phosphorylation site of Ser19 (A-V-SP-E-Q)
100 μg
Primary
Human, Mouse, Rat
Antibody
IgG
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