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  5. Tocris Bioscience™ AZ 14145845

Tocris Bioscience™ AZ 14145845

Product Code. 30067457
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 30067457

Brand: Tocris Bioscience™ 8023/10

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This item is not returnable. View return policy

Description

Mer/Axl Dual inhibitor

AZ 14145845 is a potent, and highly selective dual Mer/Axl kinase inhibitor (pIC50 = 7 nM and 7.8 nM in pAxl and pMer, respectively). In vivo, AZ 14145845 shows dose-dependent reduction of tumor growth in the Mer and Axl kinase Ba/F3 tumor xenograft model. AZ 14145845 combined with anti-PD1 antibodies and ionizing radiation increases survival in mice with MC38 tumors in vivo. AZ 14145845 is orally bioavailable.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 3-[4-[(Dimethylamino)methyl]phenyl]-N-methyl-N-[5-[3-methyl-5-(1,3,5-trimethyl-1H-pyrazol-4-yl)-2-pyridinyl]-1,3,4-oxadiazol-2-yl]imidazo[1,2-a]pyridine-6-methanamine
CAS 2830555-70-7
Quantity 10 mg
Target Additional RTK Inhibitors
Molecular Formula C32H35N9O
Purity 0.97
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