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BD Pharmingen™ IHC Zinc Fixative
An alternative to formalin fixation of tissue for paraffin embedded sections
Brand: BD 552658
Additional Details : CAS : 5970-45-6 Weight : 0.62000kg Transport : UN number : 3082 Chem class : 9 Pack group : III
Description
Ten percent neutral buffered formalin fixes tissue by cross-linking proteins, potentially causing a conformational change or “masking” of the antigenic epitope and leading to reduced or absent antibody reactivity. Different antigen retrieval techniques are used to unmask the epitope; however, many times it is not possible to retrieve the epitope and get optimal immunohistochemical staining. In these situations the use of IHC Zinc fixative, which is a milder fixative than formalin, is recommended.
- Zinc-fixed paraffin embedded sections show very good immunostaining with many leukocytes markers and depict tissue morphology comparable to formalin-fixation
- Use of antigen retrieval techniques on the zinc-fixed paraffin sections may further enhance the antibody reactivity in some cases
There are a few antigens that are not preserved by zinc-fixation. In these situations use of fresh frozen tissue for immunohistochemical staining is the only alternative.
Specifications
| 100°C | |
| Room temperature | |
| Fixative | |
| Immunohistochemical staining | |
| Liquid |
| Clear | |
| 10 X | |
| 500mL | |
| 7.2 |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- 10X Zinc Fixative (Formalin Free)
Signal Word
- Danger
Hazard Category
- LONG-TERM AQUATIC HAZARD Chronic 2
- Serious eye damage/eye irritation Category 1
- Skin corrosion/irritation Category 2
Hazard Statement
- H315-Causes skin irritation.
- H318-Causes serious eye damage.
- H411-Toxic to aquatic life with long lasting effects.
Precautionary Statement
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P302+P352-IF ON SKIN: Wash with plenty of water/.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
Supplemental information
- MIXTURE LIST-Contains : zinc acetate, zinc chloride