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Invitrogen™ Human BMPR2, His Tag Recombinant Protein

Product Code. 15498913
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Quantity:
1 mg
10 μg
100 μg
Unit Size:
100µg
10µg
1mg
Product Code. Quantity unitSize
15498913 10 μg 10µg
15408923 100 μg 100µg
15418923 1 mg 1mg
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Product Code. 15498913

Brand: Invitrogen™ PV6256

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This item is not returnable. View return policy

Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. Recombinant human BMPR2 (174-end) was expressed using baculovirus in Sf9 insect cells using an N-terminal His tag. , Validated in LanthaScreen™ Kinase Binding Assay, Protocols available for simple use and optimized performance, Multiple pack sizes available for convenient use Protein Form: Recombinant The gene accession number for BMPR2 is NP_001195.2.

BMPR2 is a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs that are involved in endochondral bone formation and embryogenesis. The loss of interaction and lack of phosphorylation of TCTEL1 by BMPR2 may contribute to the pathogenesis of primary pulmonary hypertension (PPH) and BMPR2 also plays an essential role in human T-cell differentiation. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kDa and type II receptors of about 70-80 kDa. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in BMPR2 have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q13873
Concentration See Label
For Use With (Application) Kinase Assay
Formulation PBS with 0.1 mM PMSF, 0.2 mM DTT, 150 mM Imidazole, 25% glycerol and no preservative; pH 7
Gene ID (Entrez) 659
Molecular Weight (g/mol) 97.1 kDa
Name Human BMPR2, His Tag
Quantity 10 μg
Gene Alias 2610024H22Rik; AL117858; AW546137; BB189135; BMP type II receptor; BMP type-2 receptor; BMP-2; BMPR2; BMPR-2; BMPR3; BMPRII; Bmpr-II; BMR2; bone morphogenetic protein receptor type 2; bone morphogenetic protein receptor type II; Bone morphogenetic protein receptor type-2; bone morphogenetic protein receptor, type II (serine/threonine kinase); bone morphogenic protein receptor, type II (serine/threonine kinase); BRK-3; Gm20272; POVD1; PPH1; T-ALK; type II activin receptor-like kinase; type II receptor for bone morphogenetic protein-4
Common Name BMPR2
Protein Length 174-end
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag His-tag
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Expression System Baculovirus
Form Liquid
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