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  5. Tocris Bioscience™ C25-140

Tocris Bioscience™ C25-140
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Product Code. 18766926
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18766926

Brand: Tocris Bioscience™ 7715/10

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284.40 EUR valid until 2025-12-16
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Description

TRAF6-Ubc13 interaction inhibitor

C25-140 binds directly to TNF receptor-associated factor 6 (TRAF6) and inhibits its interaction with ubiquitin-conjugating enzyme Ubc13. C25-140 reduces TRAF6-Ubc13 activity and decreases NF-κB activation and inflammatory signaling in vitro. C25-140 exhibits selectivity for TRAF6 over other E3 ligases except cIAP1. In in vivo mouse models of autoimmune psoriasis and rheumatoid arthritis, the compound improves disease symptoms. The compound also suppresses the pro-inflammatory signaling activity of IL-17A and prevents its inhibitory effect on the anti-HBV action of IFN-α HepG2 cells.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
CAS 1358099-18-9
Quantity 10 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C26H31N7O
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