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Eurofins DiscoverX CaM Kinase IV Protein, Active
Description
Ca2+/Calmodulin-Dependent Kinase family includes CaM Kinases I through IV. All CaM kinases are able to phosphorylate nuclear transcription factors in vitro at sites that either activate or repress gene expression. Ca(2+)/calmodulin-dependent protein kinase IV (CaMKIV) is a monomeric, multifunctional serine/threonine protein kinase that is expressed in subanatomic regions of the central and peripheral nervous system, T lymphocytes, and male germ cells. It is frequently localized to the nucleus, where it serves as a mediator of Ca(2+)-dependent gene expression Inhibition of CAMKIV may be useful in the treatment of anxiety and stress-related disorders through decrease in corticoropin-releasing hormone (CRH), several cancers (e.g., small cell lung, hepatocellular, ovarian) and sperm motility.
GenBank D30742
Specifications
Specifications
| Formulation | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Molecular Weight (g/mol) | 52.9 kDa |
| Quantity | 10 μg |
| Species | Human |
| Recombinant | Recombinant |
| Protein Tag | C-terminal 6His |
| Expression System | Recombinant enzyme expressed in Sf21 insect cells |
| Protein Form | Full-length |
| Purity or Quality Grade | ≥70% |
| Protein | CaM Kinase IV, active |
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