missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. Tocris Bioscience™ Cambinol

Tocris Bioscience™ Cambinol
GREENER_CHOICE

Product Code. 18765386
Click to view available options
Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
This item is not returnable. View return policy

Product Code. 18765386

Brand: Tocris Bioscience™ 7137/10

Please to purchase this item. Need a web account? Register with us today!

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance.
 View alternative products

This item is not returnable. View return policy

Description

nSMase2 inhibitor

Cambinol is a neutral sphingomyelinase-2 (nSMase2) inhibitor (Ki = 7 μM; IC50 ∼ 7.7 μM). In vitro, Cambinol suppresses extracellular vesicle production and inhibits cell-to-cell tau propagation in tau biosensor cells. In vivo, Cambinol decreases tumor necrosis factor-α or interleukin-1β-induced increases of ceramide and cell death in primary neurons. Cambinol is neuroprotective and brain penetrant. Cambinol inhibits the activity of human SIRT1 and SIRT2 and exerts antitumor activity in vitro and in mouse xenograft studies.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material 2,3-Dihydro-5-[(2-hydroxy-1-naphthalenyl)methyl]-6-phenyl-2-thioxo-4(1 H)-pyrimidinone
CAS 14513-15-6
Quantity 10 mg
Target SMPD2
Molecular Formula C21H16N2O2S
Purity 0.98
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.