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CD127 Rat anti-Mouse, PE-Cyanine5, Clone: A7R34, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 15-1271-81

Additional Details : Poids : 0.25000kg

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Product Code. 15380500

  • 134.00€ / 50µg


Expédition estimée
26-10-2020
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Description

Description

00-8222) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (cat. 00-5333) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically. Excitation: 488-561 nm; Emission: 667 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. CD127 (Interleukin-7, IL-7) is a glycoprotein involved in the regulation of lymphopoiesis. The response of cells to CD127 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is an alpha/gamma chain heterodimer. CD127 consists of an alpha chain and a gamma chain. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. CD127 promotes the proliferation of precursor B cells, thymocytes, T cell progenitors, and mature CD4+ and CD8+ T cells. The biological effects of IL7 are mediated by the binding of IL7 to the specific cell surface receptor. Diseases associated with CD127 dysfunction include severe combined immunodeficiency and T cell negative/B cell negative/NK positive severe combined immunodeficiency.
Specifications

Specifications

CD127
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P16872
CD127, IL-7Ralpha, MGC107557
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
A7R34
PE-Cyanine5
Il7r
Liquid
Il7r
IgG2a, kappa
50 μg
4° C, store in dark, DO NOT FREEZE!
Primary
16197
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