CD150 Rat anti-Mouse, PE, Clone: 9D1, eBioscience™
Rat Monoclonal Antibody
Marque: Affymetrix eBioscience 12-1501-80
Informations supplémentaires : Poids : 0.25000kg
DescriptionExcitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser. Filtration: 0.2 μm post-manufacturing filtered. CD150 (SLAM, Signaling Lymphocyte Activation Molecule) belongs to the immunoglobulin gene superfamily, and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form, the soluble form and the cytoplasmic isoforms of SLAM. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells. Moreover, CD150 is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations CD150 gene may be associated with X-linked lympho-proliferative disease (XLP).
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|CD150, CDw150, SLAM, IPO-3, signaling lymphocytic activation molecule, SLAMF1|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.