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CD172a (SIRP alpha) Rat anti-Mouse, APC, Clone: P84, eBioscience™

Rat Monoclonal Antibody

Brand:  Affymetrix eBioscience 17-1721-80

Additional Details : Poids : 0.25000kg

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Product Code. 15380690

  • 131.00€ / 25µg


Expédition estimée
06-10-2020
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Description

Description

Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser. Filtration: 0.2 μm post-manufacturing filtered. CD172a, also known as signal-regulatory protein alpha, is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and haematopoietic stem cells. CD172a acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. Ligand binding of CD172a to integrin-associated protein CD47, results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of CD172a, mediating the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. These then act as regulators of cellular function, through dephosphorylation of specific substrates. Ligation of CD172a with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs.
Specifications

Specifications

CD172a (SIRP alpha)
Monoclonal
0.2 mg/mL
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2
P97797
Sirpa
IgG1, kappa
25 μg
4° C, store in dark, DO NOT FREEZE!
Primary
19261
Flow Cytometry
P84
APC
Sirpa
Liquid
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
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