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CD279 (PD-1) Monoclonal Antibody (RMP1-14), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

124.00€ - 2045.00€

Specifications

Antigen CD279 (PD-1)
Clone RMP1-14
Concentration 1 mg/mL
Applications Flow Cytometry, Functional Assay
Classification Monoclonal
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15288847
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Affymetrix eBioscience
16-9982-85
500 μg
386.00€
500µg
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15577836
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Affymetrix eBioscience
16-9982-38
5 mg
2045.00€
5mg
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Estimated Shipment: 06-05-2024
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15278847
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Affymetrix eBioscience
16-9982-81
50 μg This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance.
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Description

Description

Description: This antibody reacts with mouse PD-1 (programmed death-1), a 55 kDa member of the Ig superfamily. PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) and plays a key role in peripheral tolerance and autoimmune disease in mice. PD-1 is expressed mainly on activated T and B lymphocytes. Two novel B7 Family members have been identified as PD-1 ligands, PD-L1 (B7-H1) and PD-L2 (B7-DC). Evidence reported to date suggests overlapping functions for these ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Similar to J43, another mAb to mouse PD-1 (Cat. No. 16-9985), RMP1-14 blocks the binding of both B7-H1-Ig and B7-DC-Ig to PD-1 transfectants. Applications Reported: The RMP1-14 antibody has been reported for use in flow cytometric analysis. Applications Tested: The RMP1-14 antibody has been tested by flow cytometric analysis of 3 day Con A activated splenocytes. This can be used at less than or equal to 1 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment.

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "e;danger signals"e; such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.
Specifications

Specifications

CD279 (PD-1)
1 mg/mL
Monoclonal
Liquid
RUO
PBS with no preservative; pH 7.2
18566
IgG2a κ
Affinity chromatography
Antibody
RMP1-14
Flow Cytometry, Functional Assay
Functional Grade
Rat
Mouse
Q02242
Pdcd1
Primary
4° C
Pdcd1
Videos
SDS
Documents

Documents

Product Certifications

For Research Use Only.