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CD282 (TLR2) Rat anti-Mouse, Functional Grade, Clone: 6C2, eBioscience™

Rat Monoclonal Antibody

Marque:  Affymetrix eBioscience 16-9021-83

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15268817

  • 345.00€ / 200µg


Date dexpédition estimée
du fournisseur 23-01-2020
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Description

Description

A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.
Spécification

Spécification

CD282 (TLR2)
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
Q9QUN7
TIL4; Toll-like Receptor 2; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Control, Flow Cytometry, Functional Assay
6C2
Functional Grade
Tlr2
Liquid
Tlr2
IgG2b, kappa
200 μg
4° C
Primary
24088
Vidéos
Documents

For Research Use Only.