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CD3 Mouse anti-Human, Clone: UCHT1, eBioscience™

Mouse Monoclonal Antibody

Marque:  Affymetrix eBioscience 14-0038-80

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15286737

  • 52.00€ / 25µg


Date dexpédition estimée
du fournisseur 20-11-2019
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Description

Description

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.
Spécification

Spécification

CD3
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P04234, P07766, P20963, P09693
FLJ18683; T3E; TCRE; HCD3
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
UCHT1
Unconjugated
CD3E
Liquid
CD247, CD3D, CD3E, CD3G
IgG1, kappa
25 μg
4° C
Primary
915, 916, 917, 919
Vidéos
Documents

For Research Use Only.