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CD366 (TIM3) Rat anti-Mouse, Clone: RMT3-23, eBioscience™

Rat Monoclonal Antibody

Marque:  Affymetrix eBioscience 14-5870-82

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15287527

  • 210.00€ / 100µg


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Description

Description

Applications Tested: This RMT3-23 antibody has been tested by flow cytometric analysis of CD366 transfected cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Purity: Greater than 90%, as determined by SDS-PAGE. Aggregation: Less than 10%, as determined by HPLC. Filtration: 0.2 μm post-manufacturing filtered. TIM3 (Hepatitis A virus cellular receptor 2, HAVCR2, T-cell immunoglobulin, mucin-dmain containing-3) is a 281 amino acid long, Type-1 Th1- specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. TIM3 consists of an IgV-like domain, a mucin-like domain in the extracellular region, and a conserved Tyrosine phosphorylation motif in the cytoplasmic region. TIM3 is involved in macrophage activation and induction of autoimmune diseases. Further, TIM3 down-regulates aggressive Th1-mediated immune responses and facilitates in the development of immune tolerance. Pathological significance of TIM3 has been attributed to Experimental autoimmune encephalomyelitis (EAE), a Th-1 dependent autoimmune disease, and also enhances the severity of experimental autoimmune encephalomyelitis in mice.
Spécification

Spécification

CD366 (TIM3)
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Q8VIM0
HAVCR2,TIM-3
Rat
Affinity chromatography
RUO
Antibody
Monoclonal
Mouse
Flow Cytometry
RMT3-23
Unconjugated
Havcr2
Liquid
Havcr2
IgG2a, kappa
100 μg
4° C
Primary
171285
Vidéos
Documents

For Research Use Only.