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CD42b Mouse anti-Human, Clone: HIP1, eBioscience™

Mouse Monoclonal Antibody

Marque:  Affymetrix eBioscience 14-0429-80

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15286947

  • 44.15€ / 25µg


Date dexpédition estimée
du fournisseur 28-08-2019
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Description

Description

CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
Spécification

Spécification

CD42b
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
P07359
GPIb alpha, GP1Ba
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Flow Cytometry, Functional Assay, Immunohistochemistry, Neutralization, Western Blot
HIP1
Unconjugated
GP1BA
Liquid
GP1BA
IgG1, kappa
25 μg
4° C
Primary
2811
Vidéos
Documents

For Research Use Only.