CD45 Rat anti-Mouse, Biotin, Clone: 30-F11, eBioscience™
Rat Monoclonal Antibody
Marque: Affymetrix eBioscience 13-0451-82
Informations supplémentaires : Poids : 0.25000kg
DescriptionCD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and maligt, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.
|PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2|
|Cluster designation 45; common leukocyte antigen; T220 and B220; HCD45|
|4° C, store in dark, DO NOT FREEZE!|
For Research Use Only.