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CD8a Rat anti-Mouse, FITC, Clone: 53-6.7, eBioscience™
Rat Monoclonal Antibody
Marque: Affymetrix eBioscience 11-0081-82
Informations supplémentaires : Poids : 0.25000kg
Description
CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).Spécification
CD8a | |
Monoclonal | |
0.5 mg/mL | |
PBS with 0.1% gelatin and 0.09% sodium azide; pH 7.2 | |
P01731 | |
CD8, Leu-2, MAL, p32, CD8a | |
Rat | |
Affinity chromatography | |
RUO | |
Antibody | |
Monoclonal | |
Mouse |
Flow Cytometry | |
53-6.7 | |
FITC | |
Cd8a | |
Liquid | |
Cd8a | |
IgG2a, kappa | |
100 μg | |
4° C, store in dark, DO NOT FREEZE! | |
Primary | |
12525 |
For Research Use Only.