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  4. Invitrogen™ Human CSNK1E (CK1 epsilon) [R178C], GST Tag Recombinant Protein

Invitrogen™ Human CSNK1E (CK1 epsilon) [R178C], GST Tag Recombinant Protein

Product Code. p-7180961
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Quantity:
1 mg
10 μg
100 μg
Unit Size:
100µg
10µg
1mg
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Product Code. 15960403

Brand: Invitrogen™ A33498

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Description

Recombinant Protein

For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 μg, 10 μg and 20 μg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 μL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase. This CSNK1E (CK1 epsilon) R178C recombinant human protein (full length) was expressed in insect cells. CSNK1E (CK1 epsilon) R178C recombinant human protein is also available in our SelectScreen™ Kinase Profiling Service. Validated for use with the Z'-LYTE™ assay Available in multiple pack sizes for convenient use Also available in our SelectScreen Kinase Profiling Service Protein Form: Full Length, Recombinant, Active The gene accession number for CSNK1E (CK1 epsilon) [R178C] is NP_001885.1.

CSNK1E serine/threonine kinase is a member of the CK1 family which plays an important role in diverse cell processes, including DNA replication and repair. CSNK1E is a regulator of Yes-associated protein (YAP) transcription coactivator, which is a key regulator of organ size and a candidate human oncogene. CSNK1E is activated by CCK2R and then phosphorylates PKD2 at Ser244. Phosphorylation of PKD2 leads to its nuclear accumulation and efficient phosphorylation of nuclear PKD2 substrates in human gastric cancer cells. CSNK1E can phosphorylate topoisomerase (topo) II alpha at serine-1106 and this regulates the enzyme activity and sensitivity to topo II-targeted drugs.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P49674
Concentration See Label
For Use With (Application) Kinase Assay
Formulation 50mM tris HCl with 25% glycerol, 0.1mM PMSF, 0.25mM DTT, 0.1mM EDTA, 150mM NaCl, 10mM glutathione and no preservative; pH 7.5
Gene ID (Entrez) 1454
Molecular Weight (g/mol) 73.6 kDa
Name Human CSNK1E (CK1 epsilon) [R178C], GST Tag
pH Range 7.5
Purification Method Purified
Quantity 10 μg
Storage Requirements -80°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Gene Alias CK1
Common Name CK1 epsilon (R178C Mutant)
Gene Symbol CSNK1E
KinaseFamily CK1 Kinase Family
Product Type Protein
Conjugate Unconjugated
Species Human
Recombinant Recombinant
Protein Tag GST-tag
Sequence Full length
Content And Storage -80°C, Avoid Freeze/Thaw Cycles
Shipping Condition Dry Ice
Expression System Insect cells
Protein Family Kinases & Inhibitors
Protein Form Full Length, Recombinant, Mutant
Form Liquid
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