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  5. Tocris Bioscience™ Dorsomorphin dihydrochloride

Tocris Bioscience™ Dorsomorphin dihydrochloride
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Product Code. 18055202
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18055202

Brand: Tocris Bioscience™ 3093/50

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Description

Potent AMPK inhibitor

Dorsomorphin dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM). Displays no significant activity on several structurally related kinases including ZAPK, SYK, PKCθ, PKA and JAK3. Inhibits AMPK activation induced by AICAR (Cat. No. 2840) and Metformin (Cat. No. 2864). Dorsomorphin dihydrochloride also inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6), promotes cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro and promotes neural differentiation of hPSCs as part of a chemical cocktail. Shown to induce autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 1219168-18-9
Molecular Formula C24H27Cl2N5O

Specifications

Quantity 50 mg
Formula Weight 472.41
Purity >98%
Molecular Weight (g/mol) 472.414
Chemical Name or Material Dorsomorphin dihydrochloride
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