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Eurofins DiscoverX Flt-3 Protein, Active

Product Code. 17300254
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Quantity:
10 μg
250 μg
Unit Size:
10µg
250µg
This item is not returnable. View return policy

Product Code. 17300254

Brand: Eurofins DiscoverX 14500

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This item is not returnable. View return policy

Description

Active, N-terminal GST tagged, recombinant human Flt3, amino acids 564 - end, for use in Kinase Assays.

The receptor tyrosine kinase FLT-3 (fms-related tyrosine kinase 3, STK1) appears to play an important role in the development of hematopoietic stemcells, dendritic cells, B progenitor cells, and natural killer (NK) cells. On binding FLT3 ligand, the wild-type receptor dimerizes, activating its tyrosine kinase domain with resultant autophosphorylation. RAS-GAP, PLC-g, PI3-kinase, STAT5, and ERK1/2 are important signaling proteins linked to activation of FLT3. FLT3 is aberrantly expressed in the malignant cells in the majority of patients with acute myeloid leukemia (AML).

GenBank NM_004119

Specifications

Formulation mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 150 mM NaCl, 0.1 mM EGTA, 270 mM sucrose, 0.03% Brij-35, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molecular Weight (g/mol) 77.4 kDa
Quantity 10 μg
Species Human
Recombinant Recombinant
Protein Tag N-terminal GST
Expression System Recombinant enzyme expressed in Sf21 insect cells
Protein Form Truncated
Purity or Quality Grade ≥68%
Protein Flt3, active
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