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TCR gamma/delta Mouse anti-Human, Clone: B1.1, eBioscience™

Mouse Monoclonal Antibody

Marque:  Affymetrix eBioscience 14-9959-82

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15278277

  • 98.50€ / 100µg


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Description

Description

TCR gamma/delta (T-cell receptor gamma/delta) are specialized T-cells in the immune system. The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory auto-destructive reactions and are believed to be a method by which the immune system compensates for disease. Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). However, a small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have shown antitumor and immunoregulatory activity.
Spécification

Spécification

TCR gamma/delta
Monoclonal
0.5 mg/mL
PBS with 0.09% sodium azide; pH 7.2
Liquid
TRD
IgG1, kappa
100 μg
4° C
Primary
6964
Flow Cytometry
B1.1
Unconjugated
TRD
T-cell receptor gamma, t-cell receptor delta, TCRd, TCRg, TCR delta gamma, TCR-CD3 complex
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
Vidéos
Documents

For Research Use Only.