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  5. Tocris Bioscience™ GT 949

Tocris Bioscience™ GT 949
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Product Code. 18785718
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18785718

Brand: Tocris Bioscience™ 6578/10

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This item is not returnable. View return policy

Description

Potent and selective positive allosteric modulator of EAAT2

GT 949 is a potent and selective EAAT2 positive allosteric modulator (EC50 = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Enhances glutamate uptake by cultured astrocytes by approximately 58%. Exhibits no significant effect on DAT, SERT and NET or NMDA receptors. Neuroprotective in an in vitro model of excitotoxicity.
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Specifications

Chemical Name or Material 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
CAS 460330-27-2
Quantity 10 mg
Molecular Formula C30H37N7O2
Purity 98%
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