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  5. Tocris Bioscience™ H 151

Tocris Bioscience™ H 151
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Product Code. 18717606
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18769306 50 mg 50mg
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Product Code. 18717606 Supplier Tocris Bioscience™ Supplier No. 6675/10

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Description

STING antagonist

H 151 is a STING antagonist. Covalently binds STING at Cys91, blocking palmitoylation and preventing assembly of STING clusters. Decreases inflammatory cytokine production in human and mouse cells in vitro. Also blocks CMA (Cat. No. 6677) -induced increases in levels of inflammatory cytokines in mice, and alleviates systemic inflammation in a mouse model of autoinflammatory disease.
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Specifications

Chemical Name or Material N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
CAS 941987-60-6
Synonym ERIS, hMITA, MITA, mitochondrial mediator of IRF3 activation, MPYS, NET23, N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner, sting, transmembrane protein 173
Quantity 10 mg
Target STING Antagonists
Molecular Formula C17H17N3O
Formula Weight 279.34
Purity 98%
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