missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Recombinant Proteins
  4. Gibco™ Human B7-H2 Fc Recombinant Protein, PeproTech®

Gibco™ Human B7-H2 Fc Recombinant Protein, PeproTech®

Product Code. 17862993
Click to view available options
Quantity:
1 mg
100 μg
20 μg
250 μg
500 μg
Unit Size:
100µg
1mg
20µg
250µg
500µg
This item is not returnable. View return policy

Product Code. 17862993

Brand: Gibco™ 31037250UG

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Recombinant Protein

PeproTech's CHO cell-derived Recombinant Human B7-H2 Fc is a glycosylated, disulfide-linked homodimer of 942 amino acid residues whose monomer consists of the 238-amino-acid length extracellular portion of B7-H2 fused to the 231-amino-acid length Fc portion of human IgG1 by two glycines. The calculated molecular weight of Recombinant Human B7-H2 Fc dimer is 104.9 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 90-95 kDa by SDS-PAGE analysis under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Inducible co-stimulator ligand (ICOSL) is a specific ligand on antigen-presenting cells and cells of the peripheral tissue that binds to the inducible co-stimulator receptor (ICOS). ICOS belongs to the CD28/CD152 receptor family that regulates T-cell activation and function. ICOSL is expressed on monocytes, dendritic cells and B cells and can be induced by inflammatory stimuli in peripheral tissue. Binding to ICOSL delivers a co-stimulatory signal for T cell proliferation and cytokine secretion.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number O75144
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 23308
Molecular Weight (g/mol) 104.9 kDa
Name Human B7-H2 Fc
Quantity 250 μg
Source CHO cells
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias AU044799; B7 homolog 2; B7 homologue 2; B7h; B7H2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP1; B7RP-1; BG071784; CD275; GI50; GL50; GL50-B; ICOS ligand; ICOSL; ICOS-L; ICOSLG; inducible T-cell costimulator ligand; inducible T-cell co-stimulator ligand; KIAA0653; LICOS; Ly115l; mKIAA0653; RGD1562791; transmembrane protein B7-H2 ICOS ligand
Common Name CD275 (B7-H2)
Gene Symbol ICOSLG
Biological Activity Determined by its ability to induce adhesion in Jurkat cells activated by immobilized anti-CD3. The ED50 for this effect is 0.3-0.6 ug/ml
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag Fc-tag
Sequence DTQEKEVRAM VGSDVELSCA CPEGSRFDLN DVYVYWQTSE SKTVVTYHIP QNSSLENVDS RYRNRALMSP AGMLRGDFSL RLFNVTPQDE QKFHCLVLSQ SLGFQEVLSV EVTLHVAANF SVPVVSAPHS PSQDELTFTC TSINGYPRPN VYWINKTDNS LLDQALQNDT VFLNMRGLYD VVSVLRIART PSVNIGCCIE NVLLQQNLTV GSQTGNDIGE RDKITENPVS TGEKNAATGG PKSCDKTHTC PPCPAPELLG GPSVFLFPPK PKDTLMISRT PEVTCVVVDV SHEDPEVKFN WYVDGVEVHN AKTKPREEQY NSTYRVVSVL TVLHQDWLNG KEYKCKVSNK ALPAPIEKTI SKAKGQPREP QVYTLPPSRD ELTKNQVSLT CLVKGFYPSD IAVEWESNGQ PENNYKTTPP VLDSDGSFFL YSKLTVDKSR WQQGNVFSCS VMHEALHNHY TQKSLSLSPG K
Content And Storage -20°C
Expression System CHO cells
Form Lyophilized
Purity or Quality Grade ≥ 95% by SDS-PAGE gel and HPLC analyses.
Show More Show Less
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.