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Gibco™ Human CD142 Recombinant Protein, PeproTech®

Product Code. 17810233
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Quantity:
1 mg
10 μg
100 μg
2 μg
250 μg
50 μg
500 μg
Unit Size:
100µg
10µg
1mg
250µg
2µg
500µg
50µg
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Product Code. 17810233

Brand: Gibco™ 15019T10UG

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This item is not returnable. View return policy

Description

Recombinant Protein

PeproTech's CHO cell-derived Recombinant Human Tissue Factor is a homodimeric glycoprotein comprised of the 227-amino-acid length monomer containing a C-terminal His-Tag and has a calculated molecular weight of 51.6 kDa. Due to glycosylation, Recombinant Human Tissue Factor migrates with an apparent molecular mass of approximately 40-50 kDa by SDS-PAGE gel under reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P13726
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 2152
Molecular Weight (g/mol) 51.6 kDa
Name Human CD142
Quantity 10 μg
Source CHO cells
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias AA409063; CD142; Cf3; Cf-3; Coagulation factor III; coagulation factor III (thromboplastin, tissue factor); coagulation factor III, tissue factor; F3; TF; TFA; Thromboplastin; Tissue factor
Common Name CD142
Gene Symbol F3
Biological Activity Functional activity of Tissue Factor is determined by its ability to activate fluorogenic peptide substrate Boc-VPR-AMC cleavage, when bound in 1:1 complex with Coagulation Factor VII.
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag His-tag
Sequence SGTTNTVAAY NLTWKSTNFK TILEWEPKPV NQVYTVQIST KSGDWKSKCF YTTDTECDLT DEIVKDVKQT YLARVFSYPA GNVESTGSAG EPLYENSPEF TPYLETNLGQ PTIQSFEQVG TKVNVTVEDE RTLVRRNNTF LSLRDVFGKD LIYTLYYWKS SSSGKKTAKT NTNEFLIDVD KGENYCFSVQ AVIPSRTVNR KSTDSPVECM GGEKGEFREH HHHHHHH
Content And Storage -20°C
Expression System CHO cells
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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