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Gibco™ Human DKK-2 Recombinant Protein, PeproTech®

Product Code. 17821053
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500 μg
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10µg
1mg
250µg
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500µg
50µg
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Product Code. 17821053

Brand: Gibco™ 12045500UG

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This item is not returnable. View return policy

Description

Recombinant Protein

Recombinant Human DKK-2 expressed in CHO cells is a glycoprotein that has a calculated molecular weight of 25.8 kDa and contains 234 amino acid residues. Due to glycosylation, human DKK-2 migrates at an apparent molecular weight of approximately 31-36 kDa by SDS-PAGE analysis under non-reducing conditions. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q9UBU2
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 27123
Molecular Weight (g/mol) 25.8 kDa
Name Human DKK-2
Quantity 500 μg
Source CHO cells
Regulatory Status RUO
Endotoxin Concentration <1 EU/ μg
Gene Alias dickkopf 2; dickkopf 2 homolog; Dickkopf gene 2; dickkopf homolog 1; dickkopf homolog 2; dickkopf homolog 2 (Xenopus laevis); dickkopf homolog 4; dickkopf related protein-2; dickkopf WNT signaling pathway inhibitor 2; dickkopf-2; Dickkopf-related protein 2; DKK2; DKK-2; Dkk4; hDkk-2; mDkk-2; UNQ682/PRO1316
Common Name DKK2
Gene Symbol DKK2
Biological Activity Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3 E1 cells. The expected ED50 for this effect is 0.5-1.0 ug/ml
Conjugate Unconjugated
Recombinant Recombinant
Sequence SQIGSSRAKL NSIKSSLGGE TPGQAANRSA GMYQGLAFGG SKKGKNLGQA YPCSSDKECE VGRYCHSPHQ GSSACMVCRR KKKRCHRDGM CCPSTRCNNG ICIPVTESIL TPHIPALDGT RHRDRNHGHY SNHDLGWQNL GRPHTKMSHI KGHEGDPCLR SSDCIEGFCC ARHFWTKICK PVLHQGEVCT KQRKKGSHGL EIFQRCDCAK GLSCKVWKDA TYSSKARLHV CQKI
Content And Storage -20°C
Expression System CHO cells
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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