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Gibco™ Human IL-6, Animal-Free Recombinant Protein, PeproTech®

Artikelnummer. 17896758
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Quantity:
250 μg
5 μg
50 μg
Pakningsstørrelse:
250µg
50µg
5µg
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Artikelnummer. 17896758

Brand: Gibco™ AF20006250UG

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Beskrivelse

Recombinant Protein

Recombinant Human IL-6 is a 20.9 kDa protein containing 184 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.
TRUSTED_SUSTAINABILITY

Tekniske data

Accession Number P05231
For Use With (Application) Functional Assay
Format Lyophilized
Formulation protein with no preservative
Gene ID (Entrez) 3569
Molecular Weight (g/mol) 20.9 kDa
Name Human IL-6, Animal-Free
Purification Method HPLC, SDS-PAGE
Quantity 250 μg
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/ μg
Gene Alias B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF2; BSF-2; CDF; CHIL-6; CTL differentiation factor; cytokine; HGF; H-IL-6; HSF; hybridoma growth factor; Ifnb2; IFN-beta-2; Il6; IL-6; ILg6; ILN; interferon beta-2; Interleukin; interleukin 6; Interleukin 6 (interferon, beta 2); interleukin 6 precursor; interleukin BSF-2; interleukin HP-1; Interleukin6; Interleukin-6; interleukin-6 precursor; interleukin-6 protein; M-IL-6; prointerleukin 6; R-IL-6
Common Name IL-6
Gene Symbol Il6
Biological Activity Determined by its ability to stimulate the proliferation of mouse B9 cells.
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Sequence PVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
Content And Storage -20°C
Activity Determined by its ability to stimulate the proliferation of mouse B9 cells.
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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