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  5. Tocris Bioscience™ BIO 5192

Tocris Bioscience™ BIO 5192
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Product Code. 18741058
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18741058

Brand: Tocris Bioscience™ 5051/50

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This item is not returnable. View return policy

Description

Highly potent and selective inhibitor of integrin α4β1

BIO 5192 is a highly selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM). Selectively binds α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). Decreases oxidative damage and improves neurological function following spinal cord injury in rats.
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Specifications

Quantity 50 mg
Product Type BIO 5192
Purity >98%
Molecular Weight (g/mol) 817.78
Inhibitors BIO 5192

For Research Use Only

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