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Invitrogen™ PAI1 Human ELISA Kit

For the quantitative detection of human PAI-1.

Brand:  Invitrogen™ BMS2033TEN

Additional Details : Weight : 0.10000kg

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Product Code. 15132829

  • 3260.00€ / 960 tests


Estimated Shipment
23-04-2021
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Includes: Aluminium pouch(es) with a Microwell Plate coated with monoclonal antibody to human PAI-1
Biotin-Conjugate anti-human PAI-1 polyclonal antibody
Streptavidin-HRP
Human PAI-1 Standard lyophilized, 10000pg/mL upon reconstitution
Assay Buffer Concentrate 20x (PBS with 1% Tween 20 and 10% BSA)
Wash Buffer Concentrate 20x (PBS with 1% Tween 20)
Substrate Solution (tetramethyl-benzidine)
Stop Solution (1M Phosphoric acid)
Blue-Dye
Green-Dye
Red-Dye
Adhesive Films

Description

Description

PAI1 (plasminogen activator inhibitor 1) belongs to serine protease inhibitor superfamily, and is the principal inhibitor of tissue-type and urokinase-type plasminogen activators (tPA and uPA). Platelets are the main source of the circulating PAI11, but it is synthesized and secreted by many tissue and cell types, including fibroblasts, smooth muscle cells, endothelial cells, hepatocytes, and inflammatory cells. Expression of PAI11 can be regulated at the transcriptional level by many factors including growth factors, cytokines, hormones, inflammatory factors, glucose or lipid metabolites, vascular tone regulating factors, chemicals, and other environmental or physical factors. PAI1 is present at increased levels in various disease states, and has been linked to an increased occurrence of thrombosis in obesity, thrombophilia and the metabolic syndrome. Defects in PAI-1 are characterized by abnormal bleeding. PAI1 mediates inhibition of fibrinolysis by inhibiting the activity of plasminogen activator, and may promote neuronal survival. Other defects in PAI1 are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency). Alternatively spliced transcript variants encoding different isoforms of PAI1 have been found.
Specifications

Specifications

P05121
ELISA Kit
Biotin
5054
RUO
2°C to 8°C
3 hr. 10 min.
Serpin peptidase inhibitor, PAI-E, PLANH1
4.7%
Human
29.0 pg/mL
Colorimetric Microplate Reader
HRP
78-5,000 pg/mL
ELISA
Pre-coated 96 well plate, Standard, Sample Diluent, Assay Buffer concentrate, Biotinylated Detection Antibody, SAV-HRP, Wash Buffer, Chromogen, Stop Solution, Adhesive Plate Covers
Plasma, 10 μL|Serum, 10 μL|Supernatant, 10 μL
1 hr. 20 min.
Human
5%
10 x 96 Tests
Supernatant
PAI,PAI-1,PAI1,PLANH1
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For Research Use Only