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STEMCELL Technologies Human Recombinant IL-1 beta

Product Code. 17109411
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100 μg
1000 μg
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100µg
10µg
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Product Code. 17109411

Brand: STEMCELL Technologies 78034.3

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This item is not returnable. View return policy

Description

Interleukin 1 beta

  • Interleukin 1 beta (IL-1β) is synthesized as an inactive precursor protein or pro-IL-1β
  • This precursor is cleaved intracellularly by caspase 1 (IL-1β convertase) to form the active form of the protein that is later secreted (Allan et al.) IL-1β binds to IL-1 receptor and activates intracellular signaling via the MAPK or NF-κB pathway
  • IL-1β is released by monocytes, tissue macrophages, and dendritic cells in response to infection or injury and induces expression of acute-phase proteins
  • It also promotes the infiltration of inflammatory and immunocompetent cells from the circulation into the extravascular space and affected tissues, by stimulating the expression of adhesion molecules on endothelial cells
  • IL-1β also affects other immune cells; for example, it co-stimulates T cell functions together with an antigen or mitogen
  • It also stimulates Th17 differentiation and B cell proliferation in an IL-6-dependent manner

Specifications

Quantity 1000 μg
Cell Type B Cells; Hematopoietic Stem and Progenitor Cells; T Cells; T Cells, CD4+; T Cells, CD8+
Purity or Quality Grade ≥95%
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