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STEMCELL Technologies Human Recombinant IL-13

Product Code. 17139391
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Product Code. 17139391

Brand: STEMCELL Technologies 78029

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This item is not returnable. View return policy

Description

Interleukin 13

  • Interleukin 13 (IL-13) is a cytokine important in type 2 immune responses and is expressed by T helper type 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s)
  • IL-13 binds a receptor composed of IL-4Ra and IL-13Ra1 or IL-13Ra2
  • IL-13 receptor is expressed on B cells and promotes B cell proliferation, induces class switching to IgG4 and IgE, and functions in the recruitment and activation of IgE-producing B cells
  • The receptor is also expressed on basophils, eosinophils, mast cells, endothelial cells, fibroblasts, monocytes, macrophages, respiratory epithelial cells, and smooth muscle cells
  • Signaling through the IL-13 receptor activates the JAK/STAT and IRS-1/IRS-2 pathways
  • In vivo, IL-13 has a role in resistance to extracellular helminth parasites by regulating gastrointestinal parasite expulsion, as well as in airway hyperresponsiveness, allergic inflammation, tissue remodeling, tumor cell growth, and fibrosis

Specifications

Name Interleukin-13, NC30
Quantity 100 μg
Cell Type B Cells; Hematopoietic Stem and Progenitor Cells; Monocytes
Purity or Quality Grade ≥95%
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