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IL-1 beta Mouse anti-Human, Functional Grade, Clone: CRM56, eBioscience™

Mouse Monoclonal Antibody

Marque:  Affymetrix eBioscience 16-7018-81

Informations supplémentaires : Poids : 0.01000kg

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Code produit. 15268737

  • 89.25€ / 50µg


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Description

Description

5 μg/mL has been found to neutralize by 50% the effect of 1 ng/mL human IL-1β bioactivity in a D10.G4.1 cell proliferation bioassay. Endotoxin: Less than 0.001 ng/ug antibody as determined by the LAL assay. Storage and handling: Use in a sterile environment. Filtration: 0.2 μm post-manufacturing filtered. Purity: Greater than 90%, as determined by SDS-PAGE. Endotoxin Level: Less than 0.001 ng/μg antibody, as determined by LAL assay. Aggregation: Less than 10%, as determined by HPLC. Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into the active 17 kDa protein requires the activation of inflammasomes, which are multi-protein complexes that respond to pathogens, stress conditions, and other danger signals. Inflammasome activation triggers the processing of the caspase-1 precursor into its active form, which in turn cleaves pro-IL-1 beta. IL-1 beta lacks a signal sequence peptide for classical ER/Golgi pathway and is secreted alongside caspase-1 via an alternate and incompletely understood mechanism. Although IL-1 beta is most often secreted in its active form, secretion of the uncleaved protein may be detectable under some biological conditions. IL-1 beta signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 alpha. IL-1 beta activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 beta play an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses to infection and injury. Elevated levels of IL-1 beta have been associated with many chronic inflammatory conditions IL-1 beta neutralizing antibodies potential therapeutic value.
Spécification

Spécification

IL-1 beta
Monoclonal
1 mg/mL
PBS with no preservative; pH 7.2
P01584
Interleukin-1 beta, Catabolin, IL1B
Mouse
Affinity chromatography
RUO
Antibody
Monoclonal
Human
ELISA, Functional Assay, Neutralization
CRM56
Functional Grade
IL1B
Liquid
IL1B
IgG1
50 μg
4° C
Primary
3553
Vidéos
Documents

For Research Use Only.