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IL-10 Monoclonal Antibody (JES3-12G8), Biotin, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

121.00€ - 315.00€

Specifications

Antigen IL-10
Clone JES3-12G8
Concentration 0.5 mg/mL
Applications ELISA
Classification Monoclonal
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Products 2
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15370030
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Affymetrix eBioscience
13-7109-81
50 μg
121.00€
50µg
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15380030
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Affymetrix eBioscience
13-7109-85
500 μg
315.00€
500µg
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Estimated Shipment: 07-05-2024
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Description

Description

Description: The JES3-12G8 antibody reacts with human interleukin-10 (IL-10). Applications Reported: The JES3-12G8 antibody has been reported for use in the detection of human IL-10 by ELISA. Applications Tested: The JES3-12G8 antibody has been tested as the detection antibody in a sandwich ELISA for analysis of human Interleukin-10 (IL-10) in combination with the purified JES3-9D7 (14-7108) antibody for capture and recombinant human IL-10 (14-8109) as the standard. A suitable range of concentrations of this antibody for ELISA detection is 0.5-2 μg/mL. A standard curve consisting of doubling dilutions of the recombinant standard over the range of 1000 pg/mL - 8 pg/mL should be included in each ELISA plate. Filtration: 0.2 μm post-manufacturing filtered.

IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
Specifications

Specifications

IL-10
0.5 mg/mL
Monoclonal
Liquid
RUO
PBS with 0.09% sodium azide; pH 7.2
CSIF; cytokine; Cytokine synthesis inhibitory factor; GVHDS; H-IL-10; il 10; IL10; IL-10; IL-10 precursor; IL10A; IL10X; ILN; Interleukin; interleukin 10; Interleukin10; interleukin-10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor; TGIF
IL10
Primary
4° C, store in dark, DO NOT FREEZE!
IL10
JES3-12G8
ELISA
Biotin
Rat
Human
P22301
3586
IgG2a κ
Affinity chromatography
Antibody
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