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IL-5 Monoclonal Antibody (TRFK5), Functional Grade, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

104.00€ - 1986.00€

Specifications

Antigen IL-5
Clone TRFK5
Concentration 1 mg/mL
Applications Functional Assay, Immunohistochemistry, Immunostaining, Neutralization
Classification Monoclonal
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15278747
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Affymetrix eBioscience
16-7052-81
50 μg
104.00€
50µg
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Estimated Shipment: 06-05-2024
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15288747
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Affymetrix eBioscience
16-7052-85
500 μg
352.00€
500µg
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Estimated Shipment: 06-05-2024
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15547806
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Affymetrix eBioscience
16-7052-38
5 mg
1986.00€
5mg
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Estimated Shipment: 06-05-2024
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Description

Description

Description: The TRFK5 antibody reacts with mouse and human interleukin-5 (IL-5). The TRFK5 antibody is a neutralizing antibody. Mouse IL-5 is a disulfide-linked homodimer, containing two 113 amino acid peptides; these resolve as 32-34 kDa bands in SDS-PAGE. IL-5 is produced by T cells and has been known as eosinophil-differentiating factor (EDF), B cell growth factor II (BCGFII), and T cell-replacing factor (TRF). IL-5 induces eosinophil differentiation and promotes eosinophil survival and activation. In mice, IL-5 has been shown to stimulate B cell proliferation and antibody production. Applications Reported: The TRFK5 antibody has been reported for use in ELISA capture, ELISPOT capture, neutralization of IL-5 bioactivity, and IHC. Applications Tested: The Functional Grade Purified TRFK5 antibody has been tested by LAL assay to verify low endotoxin levels, by ELISA, and in bioassay for neutralization of mouse IL-5 bioactivity. The TRFK5 antibody at 0.06 μg/mL has been found to inhibit by 50% the biological effects of 1.0 ng/mL mouse IL-5 in an MC/9 cell proliferation assay. Detailed information and protocols about cytokine bioassays and in vitro cytokine neutralization using antibodies can be found in the BestProtocols™ section.

IL-5 is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. IL-5 cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of IL-5 cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). IL-5, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. IL-5, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
Specifications

Specifications

IL-5
1 mg/mL
Monoclonal
Liquid
RUO
PBS with no preservative; pH 7.2
B-cell differentiation factor I; B-cell growth factor II; BCGF-II; colony-stimulating factor, eosinophil; cytotoxic T-lymphocyte inducer; EDF; Eosinophil differentiation factor; IL5; IL-5; ILN; Interleukin; Interleukin 5; Interleukin 5 (colony-stimulating factor eosinophil); Interleukin 5 (colony-stimulating factor, eosinophil); Interleukin5; interleukin-5; T-cell replacing factor; TRF
Il5
Primary
4° C
Il5
TRFK5
Functional Assay, Immunohistochemistry, Immunostaining, Neutralization
Functional Grade
Rat
Human, Mouse
P04401, P05113
16191, 3567
IgG1
Affinity chromatography
Antibody
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SDS
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Product Certifications

For Research Use Only.