missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 18768496

Tocris Bioscience™ JBJ-03-142-02
GREENER_CHOICE

Product Code. 18768496
Click to view available options
Quantity:
10 mg
Unit Size:
10mg
This item is not returnable. View return policy

Product Code. 18768496

Brand: Tocris Bioscience™ 6962/10

Please to purchase this item. Need a web account? Register with us today!

This item is not returnable. View return policy

Description

Highly potent EGFR and ErbB2 inhibitor; inhibts wild type and mutated receptors

JBJ-03-142-02 is a highly potent epidermal growth factor receptor (EGFR) and ErbB2 (human epidermal growth factor receptor; HER2) inhibitor. Inhibits wild type and tumorgenic mutated receptors (exon 20 insertion; Ex20Ins). Antiproliferative in vitro (IC50 values are 7.6, 30 - 95, 3.8 and 19 - 31 nM for Ba/F3 cells expressing wild type EGFR, EGFR with Ex20Ins mutation, wild type HER2 and HER2 with Ex20Ins mutation, respectively). Also inhibits other common EGFR mutants. Antiproliferative in patient-derived lung cancer cell lines.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material (4-Fluorophenyl)methyl N-[2-[(1-methyl-1 H-pyrazol-4-yl)amino]-4-pyrimidinyl]-N-[3-[(1-oxo-2-propen-1-yl)amino]phenyl]carbamate
CAS 2068806-31-3
Quantity 10 mg
Target EGF Receptor Inhibitors
Molecular Formula C25H22FN7O3
Formula Weight 2323
Purity 98%
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.