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  5. Tocris Bioscience™ JW 67

Tocris Bioscience™ JW 67

Product Code. 18736757
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18736757

Brand: Tocris Bioscience™ 4651/50

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Description

Wnt pathway inhibitor; induces degradation of active β-catenin

JW 67 is an inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Selective for the canonical Wnt pathway over the Sonic hedgehog (Shh) and NF-κB pathways. Blocks G1/S cell cycle progression in colorectal cancer (CRC) cell lines (GI50 = 7.8 μM).
TRUSTED_SUSTAINABILITY

Specifications

Purity >97%
Quantity 50 mg
Product Type JW 67
Molecular Weight (g/mol) 394.38
Inhibitors JW 67

For Research Use Only

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