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Thermo Scientific™ Lab Vision™ DOG1, Mouse Monoclonal Antibody

Obtain accurate, reproducible results in immunohistochemistry experiments with Thermo Scientific™ Dog1, Mouse Monoclonal Antibody.

Brand:  Thermo Scientific™ MS-1933-P0

Additional Details : Weight : 0.00170kg

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Product Code. 12670487

  • 135.00€ / 100µL


Estimated Shipment
19-05-2021
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Description

Description

Obtain accurate, reproducible results in immunohistochemistry experiments with Thermo Scientific™ Dog1, Mouse Monoclonal Antibody.

DOG1 is a cell surface protein of unknown function selectively expressed in gastrointestinal stromal tumors (GIST). Among GIST cases with KIT mutations the DOG1 antibody identified 11% more cases than c-Kit antibody1. DOG1 identifies vast majority of both c-Kit negative and PDGFRA mutated GIST cases that may still benefit from imatinib mesylate (Gleevac), an inhibitor of the kit tyrosine kinase2. In addition, DOG1 immunoreactivity is seen in fewer cases of mesanchymal, epithelial tumors and melanomas when compared with c-Kit. The use of this highly sensitive and specific novel marker will increase the accuracy of GIST diagnosis.

Host Species: Mouse

Clone: 1.1

Isotype: Unknown

Species Reactivity: Human. Others not known.

Immunogen: Synthetic peptide of human DOG1

Molecular Weight: 78 kDa

Positive Control: Gastrointestinal Stromal Tumors

Cellular Localization: Cytoplasmic and Membrane

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
Specifications

Specifications

Dog1
1.1
Unconjugated
Purified
Synthetic peptide of human Dog1
Primary
Human
Immunohistochemistry
200μg/mL
Purified Ab with BSA and Azide
Murine
100μL
Primary
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