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Epidermal Growth Factor Receptor/EGFR Ab-2 Mouse Monoclonal Antibody, Epredia™
Ensure accurate, reproducible results in immunoprecipitation experiments with Epredia™ Epidermal Growth Factor Receptor/EGFR Ab-2, Mouse Monoclonal Antibody.
Brand: Epredia MS-269-P1ABX
Additional Details : Weight : 1.00000kg
Description
EGFR is a type I receptor tyrosine kinase with sequence homology to erbB-1, -2, -3 -4 or HER-1, -2, -3 -4. It binds to Epidermal Growth Factor (EGF), Transforming Growth Factor-a (TGF-a), Heparin-binding EGF (HB-EGF), amphiregulin, βcellulin and epiregulin. EGFR is overexpressed in tumors of breast, brain, bladder, lung, gastric, head & neck, esophagus, cervix, vulva, ovary, and endometrium. It is predominantly present in squamous cell carcinomas.Host Species: Mouse
Clone: 225
Isotype: IgG1
Species Reactivity: Human, Chimpanzee and Monkey. Does not react with mouse and rat. Others not known.
Epitope: Extracellular domain
Immunogen: Purified EGFR from A431 cells
Molecular Weight: 170 kDa (wild type) and 145 kDa (vIII variant)
Positive Control: A431 cells
Cellular Localization: Membrane
Recommended for:
- Immunoprecipitation (Native only)
- Blocks EGF/TGFα-Induced Activation of EGFR
- Arrests Tumor Growth in vivo
- Inhibits Binding of Ab-1 (clone 528) to EGFR
Note:
USA: RUO; Int'l: RUO
Specifications
| Epidermal Growth Factor Receptor/EGFR Ab-2 | |
| Monoclonal | |
| 1mg/mL | |
| Mouse | |
| 100 μL | |
| EGFR Family | |
| Human, Non-human Primate | |
| IgG1 |
| Immunoprecipitation | |
| 225 | |
| Unconjugated | |
| Purified EGFR from A431 cells | |
| RUO | |
| Primary | |
| Concentrated |