Factor XIII A Ab-2 Rabbit Polyclonal Antibody, Epredia™

Description

Factor XIII A Ab-2 detects Factor XIII in both reduced and non-reduced forms. It does not react with human Factor XIII B-chain or human Factor XII. Factor XIII is a Β-globulin found in plasma and is composed of two subunits. Factor XIII-A is the catalytic subunit and is a dimmer of M.W. 160 kDa. Factor XIII is present in plasma as an α2Β2 heterodimer (M.W. 320 kDa); whereas in platelets, only the α2 unit exists. Factor XIIIa is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system. Factor XIII has also been used with CD34 to differentiate between dermatofibroma and dermatofibrosarcoma protuberans.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant protein corresponding to A-subunit of coagulation Factor XIII

Molecular Weight: 160 kDa (unreduced dimer); 80 kDa (reduced monomer)

Positive Control: Human recombinant Factor XIII A-subunit; Capillary hemangioma, dermatofibroma and placenta

Cellular Localization: Cytoplasmic and nuclear

Recommended for:

• Immunohistochemistry (Formalin/paraffin)
• Western Blotting

Note:

USA: RUO; Int'l: RUO