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Eurofins DiscoverX LATS2 Protein, Active
Description
LATS2 is a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
GenBank NM_014572.2 / GenBank BC038112
Specifications
Specifications
| Formulation | mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution. |
| Molecular Weight (g/mol) | 89 kDa (LATS2) and 30 kDa (MOBKL1A) |
| Quantity | 10 μg |
| Species | Human |
| Recombinant | Recombinant |
| Protein Tag | N-terminal GST / N-terminal 6His |
| Expression System | Recombinant enzyme expressed in Sf21 insect cells |
| Protein Form | Truncated |
| Purity or Quality Grade | Combined ≥52% |
| Protein | LATS2, active |
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