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Ly-6A/E (Sca-1) Monoclonal Antibody (D7), Biotin, eBioscience™, Invitrogen™

Rat Monoclonal Antibody

67.50€ - 298.00€

Specifications

Antigen Ly-6A/E (Sca-1)
Clone D7
Concentration 0.5 mg/mL
Applications Flow Cytometry
Classification Monoclonal
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Products 3
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
15269969
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Affymetrix eBioscience
13-5981-82
100 μg
129.00€
100µg
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15279969
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Affymetrix eBioscience
13-5981-85
500 μg
298.00€
500µg
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Estimated Shipment: 07-05-2024
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15259969
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Affymetrix eBioscience
13-5981-81
50 μg This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance.
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Description

Description

Description: The D7 monoclonal antibody reacts with mouse Sca-1, an 18 kDa member of the Ly-6 family of GPI-linked surface proteins. D7 reacts with both Ly-6E.1 and Ly-6A.2 molecules expressed by mouse hematopoietic stem cells, myeloid population and peripheral T and B cells. Non-activated splenocytes from Ly-6.2 strains including C57BL, SJL, 129, AKR, and others demonstrate higher frequency of D7-positive cells compared to the Ly-6.1 strains such as BALB/c, C3H, NZB and others. Sca-1 is expressed at high levels upon activation regardless of the Ly-6 haplotype. The Ly-6 family is involved in regulation and function of T cell activation. Sca-1 is a major phenotypic marker for mouse hematopoietic progenitor/stem cell subset. Applications Reported: This D7 antibody has been reported for use in flow cytometric analysis. Applications Tested: This D7 antibody has been tested by flow cytometric analysis of mouse bone marrow cells. This can be used at less than or equal to 0.5 μg per test. A test is defined as the amount (μg) of antibody that will stain a cell sample in a final volume of 100 μL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Filtration: 0.2 μm post-manufacturing filtered.

Stem Cell Antigen-1 (Sca-1) is a member of the lymphocyte antigen 6 (Ly-6) family. It is expressed on multipotent hematopoietic stem cells (HSC) and is used as a marker of HSC in mice. Sca-1 is used in combination with lineage depletion antibodies to identify murine HSC. Sca-1 can be found in fetal liver, adult bone marrow, and adult peripheral blood and spleen. Sca-1 may be involved in the regulation of B and T cell activation.
Specifications

Specifications

Ly-6A/E (Sca-1)
0.5 mg/mL
Monoclonal
Liquid
RUO
P05533, Q64253
Ly6a, Ly6e
Primary
4° C, do not freeze
D7
Flow Cytometry
Biotin
Rat
Mouse
110454, 17069
IgG2a κ
Affinity chromatography
Antibody
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