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Invitrogen™ 4-1BB Ligand Recombinant Rabbit Monoclonal Antibody (014), APC

Product Code. 17800656
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Quantité:
100 Tests
Unit Size:
100 pièces
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Product Code. Quantité Unit Size
17800656 100 Tests 100 pièces
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Product Code. 17800656 Supplier Invitrogen™ Supplier No. MA546776
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Estimated Shipment: 14-12-2026
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Description

Rabbit Recombinant Monoclonal Antibody

Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse 4-1BBL (CD137L) (Arg104-Glu309) and conjugated with APC under optimum conditions, the unreacted APC was removed. Storage: This antibody can be stored at 2C-8C for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.
TRUSTED_SUSTAINABILITY

Specifications

Antigène 4-1BB Ligand
Applications Flow Cytometry
Classification Recombinant Monoclonal
Clone 014
Concentration 100 μg/mL
Conjugué APC
Formule PBS with 0.5% BSA and 0.03% ProClin 300
Expression TNFSF9
Numéro d’ordre du gène P41274
Alias de gène 4 1 BB Ligand; 4 1 BBL; 41BB Ligand; 4-1BB ligand; 41BBL; 4-1BBL; 4-1BB-L; AI848817; CD 137 Ligand; CD 137L; CD137 Ligand; CD137L; Cd157l; CDw137L; costimulatory molecule; homolog of mouse 4-1BB-L; Ly63l; receptor 4-1BB ligand; TNFRSF9; Tnfsf9; TNLG5A; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9
Symboles de gène(s) TNFSF9
Espèces hôtes Rabbit
Immunogène Recombinant protein encoding Mouse 4-1BB Ligand (Arg104-Glu309).
Méthode de purification Protein A
Quantité 100 Tests
État réglementaire RUO
Primaire ou secondaire Primary
Identification génétique (Entrez) 21950
Espèces cibles Mouse
Contenu et stockage 4°C, store in dark, DO NOT FREEZE!
Type de produit Antibody
Forme Liquid
Isotype IgG
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