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IBA Lifesciences MHC I-Strep HLA-A*1101; CMV pp65 (GPISGHVLK)

MHC class I molecule fused to a Twin-Strep-tag™ and refolded with a peptide

Brand:  IBA Lifesciences 6-7050-001

Additional Details : Weight : 0.00010kg

Product Code. 15653928

This item has been discontinued and is no longer available. View the product for possible alternatives or contact our Technical Support team on 056 260 260 for assistance.


Description

Description

  • MHC I-Strep HLA-A*1101; CMV pp65 (16-24) (GPISGHVLK) is a recombinantly expressed MHC class I molecule that presents a peptide from a human cytomegalovirus (CMV) phosphoprotein (pp65).
  • Our MHC I Streptamer™ approach is based on our Strep-tag technology and facilitates reversible antigen-specific T cell labeling.
  • A Twin-Strep-tag™ fused to the MHC I-Strep permits multimerization of MHC I complexes on a Strep-Tactin™ backbone, resulting in the formation of MHC I Streptamers.
  • For multimerizing MHC I-Streps, Strep-Tactin™ TACS Agarose columns, Strep-Tactin™ Magnetic Microbeads or fluorophore-conjugated Strep-Tactin™ can be used.
  • This allows affinity chromatographic or magnetic isolation or cell staining for flow cytometry analysis and sorting (FACS), depending on the experimental requirements.
  • The addition of biotin reverses the multimerization of MHC class I molecules, leading to their dissociation from the target cells.
  • The resulting label-free cells are highly viable and fully functional.
    • Specifications

    Specifications

    40 μL
    Fluorescent reagent for staining, magnetic T cell labeling and isolation
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