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Gibco™ Human 4-1BB Ligand (TNFSF9), Animal-Free Recombinant Protein, PeproTech®

Product Code. 17873743
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Quantity:
1 mg
100 μg
20 μg
500 μg
Unit Size:
100µg
1mg
20µg
500µg
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Product Code. 17873743

Brand: Gibco™ AF310111MG

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Description

Recombinant Protein

Recombinant Human 4-1BB Ligand is a soluble 19.5 kDa protein consisting of 185 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. CD137L is a co-stimulatory molecule that is expressed on antigen presenting cells (DCs, monocytes/macrophages, B cells) and is upregulated upon activation. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. Activated T cells also express CD137, and engagement with CD137L enhances T cell proliferation, IL-2 secretion, survival, and cytotoxic activity. CD137L is also expressed on a majority of B-cell lymphomas, including mantle cell lymphoma, follicular lymphoma, and diffuse large B-cell lymphoma (but it is lacking on Hodgkin lymphoma and T-cell lymphoma). CD137L is also expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interactions.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number P41273
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 8744
Molecular Weight (g/mol) 19.5 kDa
Name Human 4-1 BB Ligand (TNFSF9), Animal-Free
Quantity 1 mg
Source E. coli
Regulatory Status RUO
Endotoxin Concentration <0.1 EU/ μg
Gene Alias 4 1 BB Ligand; 4 1 BBL; 41 BB Ligand; 4-1 BB ligand; 41 BBL; 4-1 BBL; 4-1 BB-L; AI848817; CD 137 Ligand; CD 137 L; CD137 Ligand; CD137L; Cd157l; CDw137L; costimulatory molecule; homolog of mouse 4-1 BB-L; Ly63l; receptor 4-1 BB ligand; TNFRSF9; Tnfsf9; TNLG5A; tumor necrosis factor (ligand) superfamily member 9; tumor necrosis factor (ligand) superfamily, member 9; tumor necrosis factor ligand 5 A; tumor necrosis factor ligand superfamily member 9; tumor necrosis factor superfamily member 9
Common Name 4-1 BBL (CD137L)
Gene Symbol TNFSF9
Biological Activity Determined by its ability to induce CD137/NF-kappaB activation in HEK293 reporter cells.
Conjugate Unconjugated
Recombinant Recombinant
Sequence MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE
Content And Storage -20°C
Expression System E. coli
Form Lyophilized
Purity or Quality Grade ≥ 98% by SDS-PAGE gel and HPLC analyses.
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