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  4. Invitrogen™ Mouse Siglec-3 (CD33) Fc Chimera Recombinant Protein

Invitrogen™ Mouse Siglec-3 (CD33) Fc Chimera Recombinant Protein

Product Code. p-200008476
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Quantity:
1 mg
100 μg
Unit Size:
100µg
1mg
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Product Code. 17926471

Brand: Invitrogen™ RP88212

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Description

Recombinant Protein

It is recommended that the protein be aliquoted for optimal storage. It is recommended that sterile water (550 μL) be added to the vial to prepare a stock solution of 1.82 mg/mL. Concentration is measured by UV.

CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies, and these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. Further, CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. CD33 is also expressed on, and is a useful marker for, peripheral monocytes. CD33 is useful for distinguishing myelogenous leukemia cells from lymphoid or erythroid leukemias. Diseases associated with CD43 dysfunction include gallbladder lymphoma and extracutaneous mastocytoma.
TRUSTED_SUSTAINABILITY

Specifications

Accession Number Q63994
For Use With (Application) Control, Neutralization
Format Lyophilized
Formulation PBS with 0.01% mannitol, 5-8% trehalose, 0.01% Tween 80 and no preservative; pH 7.4
Gene ID (Entrez) 12489
Molecular Weight (g/mol) 55-60 kDa
Name Mouse Siglec-3 (CD33) Fc Chimera
pH Range 7.4
Purification Method Purified
Quantity 100 μg
Storage Requirements -20°C, Avoid Freeze/Thaw Cycles
Regulatory Status RUO
Endotoxin Concentration <1.0 EU/μg
Gene Alias CD33; CD33 antigen; CD33 antigen (gp67); CD33 molecule; CD33 molecule transcript; FLJ00391; gp67; Myeloid cell surface antigen CD33; p67; sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3; SIGLEC3; Siglec-3
Common Name CD33
Gene Symbol CD33
Product Type Protein
Conjugate Unconjugated
Recombinant Recombinant
Protein Tag Fc-tag
Sequence Mouse CD33, amino acids Met1-Glu240 (Accession # Q63994-1) with a C-terminal human IgG1 Fc region
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Expression System HEK293 cells
Form Lyophilized
Purity or Quality Grade >90% as determined by SDS-PAGE.
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