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Tocris Bioscience™ MS 159

Product Code. 30158297
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5 mg
Unit Size:
5mg
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30158297 5 mg 5mg
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Product Code. 30158297 Supplier Tocris Bioscience™ Supplier No. 8079/5

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345.10 EUR valid until 2026-03-31
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Description

NSD2 Degrader (PROTAC™)

MS 159 is a nuclear receptor binding SET structural domain protein 2 (NSD2) Degrader (DC50 = 5.2 μM, Dmax = >82%). Also degrades IKZF3 and IKZF1. Comprises an NSD2 binding moiety joined by a linker to a cereblon E3 ligase ligand. Inhibits proliferation of KMS11 and H929 tumor cells. Bioavailable in vivo.
TRUSTED_SUSTAINABILITY

Specifications

Chemical Name or Material N-Cyclopropyl-N-(4-((5-(3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)propoxy)pyridin-2-yl)-carbamoyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide
CAS 3031353-59-7
Quantity 5 mg
Target Active Degraders
Molecular Formula C43H40N8O10
Purity 0.98
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