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  5. Tocris Bioscience™ MS 436

Tocris Bioscience™ MS 436

Product Code. p-5545906
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18747938

Brand: Tocris Bioscience™ 5173/50

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Description

Potent and selective BRD4(1) inhibitor

MS 436 is a potent and selective BRD4 bromodomain inhibitor (Ki = 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 μM, respectively). Attenuates melanoma cell proliferation in vitro.
TRUSTED_SUSTAINABILITY

Specifications

Purity >98%
Quantity 50 mg
Product Type MS 436
Molecular Weight (g/mol) 383.42
Inhibitors MS 436

For Research Use Only

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